GHK-Cu

GHK-Cu (also known as Copper Tripeptide-1, Prezatide Copper, or Glycyl-L-Histidyl-L-Lysine Copper complex) is a synthetic tripeptide complex consisting of the amino acids glycine (Gly), histidine (His), and lysine (Lys)chelated to a copper(II) ion (Cu²⁺) in a 1:1 molar ratio, forming a stable coordination complex where copper binds primarily via the histidine imidazole ring, peptide backbone nitrogens, and deprotonated amide groups.

Its amino acid sequence is: Gly-His-Lys (with Cu²⁺ coordination; abbreviated as GHK-Cu or Gly-His-Lys-Cu).

Chemically, the complex has the molecular formula C₁₄H₂₂CuN₆O₄ and a molar mass of approximately 401.91 g/mol (CAS 89030-95-5 for the copper complex; the apo-peptide GHK is C₁₄H₂₄N₆O₄, ~340.38 g/mol, CAS 49557-75-7). This metallopeptide is classified as a research chemical and is commonly utilized in laboratory investigations of copper-binding biochemistry, peptide-metal interactions, and related coordination chemistry pathways.

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